Ironclad 1 - victory vs. the Heart:
First time facing the Heart, and I won! My relic setup was pretty busted. My core damage engine was Necronomicon (the first two-cost attack I played every turn was played twice), Heavy Blade x2, Inflame x2, Vajra (+1 strength), and Red Skull (+3 strength when under 50% HP). I had a Velvet Choker for energy, Torii + Fossilized Helix (Buffer 1) for damage reduction, and Pantograph + Bird-Faced Urn for healing.
The fight against the Heart could easily have gone south, but I had Buffer to take one big hit, and I happened to draw Impervious at exactly the right time to take the next big hit. HGR, who watched me play Act 4, said: "This deck can't fucking block. It's just that you had relics to make you not take damage."